BROCHURE
Nikolitsa Nomikou is a UK,University College London,United Kingdom

Nikolitsa Nomikou

UK

Organizing Committee

United Kingdom

University College London

BIOGRAPHY

Dr Nomikou completed her doctorate in Biomedical Sciences at Ulster University in 2008. She was appointed as Lecturer in Targeted Therapeutics at UCL in September 2013 and was then promoted to Associate Professor in October 2019.

PUBLICATIONS

1. Logan K, Foglietta F, Nesbitt H, Sheng Y, McKaig T, Kamila S, Gao J, Nomikou N, Callan B, McHale AP, Callan JF. Targeted chemo-sonodynamic therapy treatment of breast tumours using ultrasound responsive microbubbles loaded with paclitaxel, doxorubicin and Rose Bengal. European Journal of Pharmaceutics and Biopharmaceutics 2019;139:224-231. 2. Mohammad Hadi M, Andini Palilu D, Ahmed H., Callan J, Macrobert A, McHale A, Nomikou N. Exploiting the tumour microenvironment in order to optimise sonodynamic therapy for prostate cancer. International Cancer Microenvironment Society Conference 2018, Lisbon, Portugal 3. Mohammad Hadi M, Andini Palilu D, Ahmed H, Callan J, Macrobert A, McHale A, Nomikou N. (2018). Multistimulus - responsive nanoparticles for optimising sonodynamic therapy in prostate cancer. 3rd ASPIC International Congress, Lisbon, Portugal 4. Nomikou N, Feichtinger GA, Saha S, Nuernberger S, Heimel P, Redl H, McHale AP. Ultrasound-responsive gene-activated matrices for osteogenic gene therapy using matrix-assisted sonoporation. Journal of Tissue Engineering and Regenerative Medicine 2018;12(1):e250-e260 5. Tarassoli S, Martinez de Pinillos S, Pye H, Mosse CA, Callan JF, Macrobert S, McHale AP, Nomikou N†. Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy. Nanotechnology (Gold open access) 2017; 28: 6. Nomikou N†, Curtis K, McEwan C, Callan B, Callan JF, McHale AP. A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy. Acta Biomaterialia 2017;49:414–421 7. Sheng Y, Beguin E, Nesbitt H, Kamila S, Owen J, Barnsley LC, Callan B, O'Kane C, Nomikou N, Hamoudi R, Taylor MA, Love M, Kelly P, O'Rourke D, Stride E, McHale AP, Callan JF. Magnetically responsive microbubbles as delivery vehicles for targeted sonodynamic and antimetabolite therapy of pancreatic cancer. J Control Release. 2017 Sep 28;262:192-200 8. McEwan C, Kamila S, Owen J, Nesbitt H, Callan B, Borden M, Nomikou N, Hamoudi RA, Taylor MA, Stride E, McHale AP, Callan JF. Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle. Biomaterials 2016;80:20-32 9. McHale AP, Callan JF, Nomikou N, Fowley C, Callan B. Sonodynamic therapy: Concept, mechanism and application to cancer treatment. Advances in Experimental Medicine and Biology 2016;880:429-50 10. Nomikou N, Feichtinger GA, Redl H, McHale AP. Ultrasound-mediated gene transfer (sonoporation) in fibrin-based matrices: potential for use in tissue regeneration. Journal of Tissue Engineering and Regenerative Medicine 2016;10(1): 29–39 11. McEwan C, Owen J, Stride E, Fowley C, Coussios C, Borden M, Nomikou N, McHale AP, Callan JF. Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. Journal of Control Release 2015;203: 51-56 12. Costley D, Mc Ewan C, Fowley C, McHale AP, Atchison J, Nomikou N, Callan JF. Treating cancer with sonodynamic therapy: A review. International Journal of Hyperthermia 2015;31(2): 107-117 13. McEwan C, Owen J, Stride E, Fowley C, Nesbitt H, Cochrane D, Coussios CC, Borden M, Nomikou N, McHale AP, Callan JF. Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. Photodiagnosis and Photodynamic Therapy 2015;12(3): 328 14. Gazouli M, Nomikou N, Callan JF, Efstathopoulos EP Novel nanotechnology approaches for targeted cancer therapy. Current Nanomedicine 2014;3: 83-88 15. McEwan C, Fowley C, Nomikou N, McCaughan B, McHale AP, Callan JF. Polymeric microbubbles as delivery vehicles for sensitizers in sonodynamic therapy. Langmuir 2014;30(49): 14926-14930 16. Feichtinger GA, Slezak P, Hofmann AT, Schuetzenberger S, Kaipel M, Schwartz E, Neef A, Nomikou N, Nau T, van Griensven M, McHale AP, Redl. Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery. Human Gene Therapy Methods 2014;25(1): 57-71 17. Fowley C, Nomikou N, McHale AP, McCaughan B, Callan JF. Extending the tissue penetration capability of conventional photosensitisers: A carbon quantum dot – protoporphyrin IX conjugate for use in two-photon excited photodynamic therapy. Chemical Communications 2013;49: 8934-8936 18. Dwivedi A, Nomikou N, Singh P, McHale AP. The effects of microencapsulated Lactobacillus casei on tumour cell growth: In vitro and in vivo studies. International Journal of Medical Microbiology 2012;302(7-8):293-299 19. Nomikou N, Fowley C, Byrne NM, McCaughan B, McHale AP, Callan JF. Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy. Chemical Communications 2012;48(67):8332-8334 20. Nomikou N, Sterrett C, Arthur C, McCaughan B, Callan JF, McHale AP. The effects of ultrasound and light on indocyanine green-treated tumour cells and tissues. ChemMedChem 2012;7:1465- 21. Nomikou N, McHale AP. Microbubble-enhanced ultrasound-mediated gene transfer - Towards the development of targeted gene therapy for cancer. (Invited review) International Journal of Hyperthermia 2012;28(4):300-310 22. Fowley C, Nomikou N, McHale AP, McCarron PA, McCaughan B, Callan JF. Water soluble quantum dots as hydrophilic carriers and two-photon excited energy donors in photodynamic therapy. Journal of Materials Chemistry 2012;22:6456-6462 23. Nomikou N, Tiwary P, Trehan T, Gulati K, McHale AP. Studies on neutral, cationic and biotinylated cationic microbubbles in enhancing ultrasound-mediated gene delivery in vitro and in vivo. Acta Biomaterialia 2012;8(3):1273-1280 24. McHale AP, Nomikou N (2012) TUMOURS OF THE CENTRAL NERVOUS SYSTEM –Vol. 4, Chapter 32. Brain tumours: pre-clinical assessment of targeted, site specific therapy exploiting ultrasound and cancer chemotherapeutic drugs. 1st edition, ISBN 978-94-007-1705-3, Springer, (USA), p.313-322 25. McCaughan B, Rouanet C, Fowley C, Nomikou N, McHale AP, McCarron PA, Callan JF. Enhanced ROS production and cell death through combined photo- and sono- activation of conventional photosensitising drugs. Bioorganic and Medicinal Chemistry Letters 2011;21(19):5750-5752 26. Nomikou N, McHale AP. Exploiting ultrasound-mediated effects in delivering targeted, site-specific cancer therapy. (Invited Review) Cancer Letters 2010;296(2): 133-143 27. Nomikou N, Li YS, McHale AP. Ultrasound-enhanced drug dispersion through solid tumours and its possible role in aiding ultrasound-targeted cancer chemotherapy. Cancer Letters 2010;288(1): 94-98

EDUCATION

University of Patras, Greece B.Sc. 04/2003 Chemistry Ulster University, United Kingdom M.Sc. 09/2004 Biotechnology/Food Biotechnology Ulster University, United Kingdom Ph.D. 08/2008 Biomedical Sciences

RESEARCH INTEREST

Dr Nomikou’s current research focuses on the development of translational drug delivery approaches based on formulations/carriers that are responsive to different forms of energy (electromagnetic fields, ultrasound), as well as responsive to the cancerous microenvironment. Her recently published and current funded research has demonstrated the potential of site-specific and minimally-invasive treatments based on low-intensity ultrasound and light, named as sonodynamic and photodynamic/photothermal therapy, respectively. The potential of these therapeutic approaches to efficiently manage aggressive and advanced-stage cancers has been strongly augmented by novel therapeutic formulations that respond to either externally-applied or tumour-specific stimuli. Dr Nomikou’s team aims to optimize these therapeutic modalities using nanotechnology for maximizing their potential in the clinic. Her research has been awarded funding from the UK Research Councils (EPSRC, MRC), the Royal Society, as well as UK-based cancer charities (e.g. Bowel & Cancer Research). Her research has also been supported with private donations.

HONORS AND AWARDS

Awarded with funding as principal investigator from the UK Engineering and Physical Sciences Research Council (EPSRC) and the Medical Research Council (MRC) (three research grants: EP/P020828/1, EP/R035008/1 and EP/N509577/1), the Royal Society UK (RG130569), the Bowel and Cancer Research (UK-registered charity) and the Therapeutic Acceleration Support Fund (UCL)

COLLABORATIONS

Professor Anthony McHale, Ulster University, UK Professor John Callan, Ulster University, UK Professor Alexander MacRobert, UCL, UK Dr Heather Nesbitt, Ulster University, UK AxisBio, UK Dr Rifat Hamoudi, University of Sharjah, United Arab Emirates Dr Georg A. Feichtinger, University of Leeds, UK Dr Maria Pia Donzello, University of Rome, Italy

EDITORSHIP

N/A

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