BROCHURE
Hongchuan is a Professor,Medical School of Zhejiang University,China

Hongchuan

Professor

Organizing Committee

China

Medical School of Zhejiang University

BIOGRAPHY

2009.12-present: Professor, SRRSH, Medical School of Zhejiang University, China

2007.11-2009.11: Research Assistant Professor, PWH, CUHK, Hong Kong

2005.11-2007.11: Postdoctoral Fellow, PWH, CUHK, Hong Kong

2004.12-2005.11: Postdoctoral Fellow, Institute for Ageing Research-FLI, Jena, Germany

1999.09-2001.07: Resident/Fellow, SRRSH, Medical School of Zhejiang University, China

PUBLICATIONS

1.       Zhu L, Zhu Y, Han S, Chen M, Song P, Dai D, Xu W, Feng L, Shin V, Wang X and Jin H*. Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer.

2.       Yang L, Ying S, Hu S, Zhao X, Li M, Chen M, Zhu Y, Song P, Zhu L, Jiang T, An H, Yousafzai NA, Xu W, Zhang Z, Wang X, Feng L*, Jin H*. EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer. 

3.       Q Li, X Fu, X Ge, F Tao, P Huang, M Ge, H Jin. Antitumor Effects and Related Mechanisms of Ethyl Acetate Extracts of Polygonum perfoliatum.

4.       Cui Y, Groth S, Troutman S, Carlstedt A, Sperka T, Riecken LB, Kissil JL, Jin H, Morrison H*. The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling. 

5.       Dai D, Zhong Y, Wang Z, Yousafzai NA, Jin H, Wang X*. The prognostic impact of age in different molecular subtypes of breast cancer: a population-based study. 

6.       Wei KL, Chou JL, Chen YC, Jin H, Chuang YM, Wu CS, Chan MWY. Methylomics analysis identifies a putative STAT3 target, SPG20, as a noninvasive epigenetic biomarker for early detection of gastric cancer.

7.       Liu M, Zhou J, Liu X, Feng Y, Yang W, Wu F, Cheung OK, Sun H, Zeng X, Tang W, Mok MTS, Wong J, Yeung PC, Lai PBS, Chen Z, Jin H, Chen J, Chan SL, Chan AWH, To KF, Sung JJY, Chen M, Cheng AS. Targeting Monocyte-intrinsic Enhancer Reprogramming Improves Immunotherapy Efficacy in Hepatocellular Carcinoma.

8.       Xu J, Shi Q, Xu W, Zhou Q, Shi R, Zhu L, Feng L, Cheng ASL, Morrison H, Wang X, Jin H*. Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance.

9.       Yousafzai AN, Zhou Q, Xu W, Shi Q, Xu J, Feng L, Chen H, Shin YV, Jin H*, Wang X*. SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer.

10.   Li Y, Sun Y, Tang T, Niu Y, Li X, Xie M, Jin H*, Mei Q*. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. 

11.   Zhou Q, Li H, Li Y, Tan M, Fan S, Cao C, Meng F, Zhu L, Zhao L, Guan MX, Jin H, Sun Y*. Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. 

12.   Shin VY, Chen J, Cheuk IW, Siu MT, Ho CW, Wang X, Jin H, Kwong A*. Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness.

13.   Dai D#, Zhou B#, Xu W, Jin H, Wang X*. CHFR Promoter Hypermethylation Is Associated with Gastric Cancer and Plays a Protective Role in Gastric Cancer Process.

14.   Sun Jie, Zhu Y, Ding Z, He X, Dong H, Feng Y, Du J, Wu X, Zhang L, Yu X, Lin A, McDonald T, Zhao D, Wu H, Hua W, Zhang B, Feng L, Tohyama K, Oberdoerffer P, Chung YJ, Aplan PD, Boultwood J, Pellagatti A, Khaled S, Kuo YH, Carlesso N, Marcucci G, Jin H*, Li L*. Activation of SIRT1 Deacetylase Ablates Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 function. 

15.   Dai D#, Han S#, Li L, Guo Y, Wei Y, Jin H and Wang X*. Anemia is associated with poor outcomes of metastatic castration-resistant prostate cancer   Am J Transl Res. 2018

16.   Yousafzai NA, Wang H, Wang Z, Zhu Y, Zhu L, Jin H, Wang X*. Exosome mediated multidrug resistance in cancer. Am J Cancer Res. 2018 Nov 1;8(11):2210-2226.

17.   Zhu L, Zhu Y, Dai D, Jin H*.  Epigenetic regulation of Alternative Splicing.

18.   Yu L#, Yang F#, Zhang F, Guo D, Li L, Wang X, Liang T, Wang J, Cai Z*, Jin H*. CD69 enhances immunosuppressive function of regulatory T cells and attenuates colitis by prompting IL-10 production. 

19.   Dai D, Jin H and Wang X*. Nomogram for predicting survival in triple-negative breast cancer patients with histology of infiltrating duct carcinoma: a population-based study.

21.   Xu W, Shi Q, Qian X, Zhou B, Xu J, Zhu L, Feng L, Jin H, Wang X*. Rab5a suppresses autophagy to promote drug resistance in cancer cells. 

22.   Xu W, Zhou B, Zhao X, Zhu L, Xu J, Jiang Z, Chen D, Wei Q, Han M, Feng L, Wang S, Wang X, Zhou J, Jin H*. KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance. 

23.   Zhu Y, Lu H, Zhang D, Li M, Sun X, Wan L, Yu D, Tian Y, Jin H, Lin A, Gao F, Lai M. Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer. 

24.   Xu W, Wei Q, Han M, Zhou B, Wang H, Zhang J, Wang Q, Sun J, Feng L, Wang S, Ye Y, Wang X, Zhou J, Jin H*. CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer. 

25.   Cheng YY, Jin HC, Chan MWY, Chu WK, Grusch M. Epigenetic Biomarkers in Cancer. 

26.   Dai D, Wang H, Zhu L, Jin H*, Wang X*. N6-methyladenosine links RNA metabolism to cancer progression.

27.   Liu L, Zhang L, Zhang L, Yang F, Zhu X, Lu Z, Yang Y, Lu H, Feng L, Wang Z, Chen H, Yan S, Wang L, Ju Z, Jin H*, Zhu X*. Hepatic Tmem30a deficiency causes intrahepatic cholestasis by impairing expression and localization of bile salt transporters .

28.   Qian X, Xu W, Li J, Xu J, Yu W, Jiang Z, Feng L, Wang X, Zhou J, Jin H*. Enolase1 stimulates glycolysis to promote chemoresistance in gastric cancer

29.   Yang L, Wang H, Shen Q, Feng L*, Jin H. Long non-coding RNAs involved in autophagy regulation. 

30.   Luo C, Chen X, Jin H*, Yao K*. The association between gout and cataract risk: A meta-analysis. 

EDUCATION

 

 

RESEARCH INTEREST

Mechanism and role of aberrant signal transudation in carcinogenesis

Epigenetic regulation of metabolism

Translational cancer research: new approaches for cancer screening and treatment

 

Upcoming Conferences